| Safari Records | 1977 | Original Production | — |
| Sanctuary Midline | — | Reissue Production | 6448 |
| Sanctuary Records | 1996 | Production | 6448 |
| Science Friction | 1992 | Reissue Production | — |
| Secret Records | 1980 | Original Production | 7935 |
| See for Miles Records | 1982 | Reissue Production | — |
| See for Miles Records | 1 January 1982 | — | private company limited by shares |
| Shogun Audio | — | Original Production | 23548 |
| Shut Up and Dance Records | 1989 | Original Production | — |
| Siege of Amida Records | 2006 | Original Production | — |
| Signature | — | Production | — |
| Signum Classics | — | Original Production | 15723 |
| Silva Screen Records | 1986 | Imprint | 7371 |
| Silvertone Records | 1988 | Original Production | 7381 |
| Siren Records | — | Original Production | — |
| Situation Two | 1981 | Original Production | — |
| Skam | 1991 | Original Production | — |
| Skint Records | — | Original Production | 1406 |
| Slam Productions | 1989 | Original Production | 5526 |
| Slip ’n’ Slide | 1991 | Original Production | 1211 |
| Smash Hits | — | Original Production | — |
| Snapper Music | 1996 | Imprint | 1770 |
| Society of Sound | May 2008 | Distributor | — |
| Soli Deo Gloria | 2005 | Original Production | 13772 |
| Some Bizzare | — | Original Production | 5661 |
| Somm Recordings | 1995 | Original Production | — |
| Songlines | — | Reissue Production | — |
| Sonic Cathedral | 2006 | Original Production | 73908 |
| Sony Music Entertainment UK | — | Holding | — |
| Sony Music UK | 30 September 2002 | Imprint | 12723 |
| Sony Soho Square | 1991 | Original Production | 6140 |
| Sotto Voce | June 2013 | Imprint | — |
| Soul Brother Records | — | Reissue Production | — |
| Soul Jazz Records | — | Reissue Production | 2678 |
| Soul:r | 21 November 2001 | Original Production | — |
| Soundway | 2002 | Imprint | — |
| Source UK | — | Original Production | — |
| Southbound | 1989 | Reissue Production | — |
| Southern Records | — | Original Production | — |
| Spearhead Records | January 2005 | Original Production | — |
| Spinefarm Records U.K. | October 2007 | Original Production | — |
| Spotlite Records | 1968 | — | — |
| Stamina Records | — | Original Production | — |
| Stateside | 15 June 1962 | Imprint | — |
| Step-1 Music | — | Production | — |
| Stiff Records | 1976 | Original Production | 4764 |
| Strange Fruit | 1986 | Production | — |
| Strictly Underground Records | 1988 | Original Production | — |
| Strut | 1999 | Production | 7306 |
| Subtitles Music | 2000 | Original Production | — |
| Sunday Best | 1997 | Original Production | — |
| Sunday Express | 1918 | — | — |
| Sunset Records | 1966 | Reissue Production | — |
| Superior Quality Recordings | 1995 | Original Production | — |
| Swan Song | 10 May 1974 | Original Production | — |
| Syco Music | 2002 | Original Production | 1413 |
| Symmetry Recordings | 2006 | Original Production | — |
| System Music | 1 January 2013 | Original Production | — |